How cannabis can help to reduce stress thanks to two of its main cannabinoids; THC and CBD. In low doses, THC does this by activating the CB-1 receptor of the endocannabinoid system (ECS) in the brain. The CB-1 receptor then regulates and decreases your stress levels, giving you a more relaxed feeling. CBD reduces your heart rate and blood pressure, by interacting with the serotonin receptor (5-HT1A). Both effects of THC and CBD are enhanced by the terpene Limonene, which on its own, also has stress reducing-properties.